Phenylketonuria and phenylalanine
A direct contraindication to the use of phenylalanine and DLPA is the genetic disease phenylketonuria. It is based on the inability of the body to produce an enzyme responsible for the conversion of the amino acid phenylalanine to tyrosine, which is the first stage of adrenaline synthesis.
Other genetic diseases
Genetic diseases, accompanied by a disorder of the conversion of amino acids, are not so common. If you have such disorders of metabolism of specific amino acids, the use of pure amino acids can cause deterioration in your condition. In case of worsening of your condition against the background of taking amino acids, immediately stop taking them and contact your doctor or a certified nutritionist under whose control you can start the program again.
Monoamine oxidase (MAO) inhibitors–Phenylalanine, Tyrosine and Tryptophan
Please do not take mixtures containing phenylalanine, tyrosine and tryptophan if you are taking monoamine oxidase inhibitors, antidepressants that are manufactured under a variety of trade names. These antidepressants inhibit the enzyme monoamine oxidase, which is used in our body to deactivate stress hormones, noradrenaline and epinephrine, and the sleep hormone serotonin, when they are no longer needed. Inhibition of this enzyme allows these hormones to circulate in the body much longer than usual, thereby reducing the symptoms of depression and stress. Unfortunately, MAO inhibitors can also lead to the depletion of a variety of essential nutrients and can lead to a variety of other diseases, such as anorexia.
If you take phenylalanine, tyrosine and tryptophan (precursors of stress and sleep hormones) together with MAO inhibitors, this will result in a surge in the level of the above hormones circulating in the blood, which can negatively affect your mood and mental state. In this case, your doctor or counselor must decide on the cotreatment. Therefore, it is better to take either MAO inhibitors or amino acids. If you want to take them together, ask your consultant.
Tryptophan and problems with the liver
Another reason to worry about taking tryptophan is that it can cause liver damage. In particular, this has to do with a hepatic coma, when the suffering liver loses many metabolic functions. Recently, there have been many publications stating that tryptophan in isolated form is not recommended for liver diseases, pregnancy, young children, and, as mentioned above, together with MAO and SSRI inhibitors. Therefore, you should consult an expert before start taking tryptophan.
Herpes and arginine
A number of clinical trials have confirmed that the amino acid arginine stimulates the growth and activity of the herpes virus.
Menstruation and histidine
Taking 4 grams of L-histidine can provoke premature onset of menstruation. In this case, it is recommended to reduce the dose of histidine or take it in smaller doses, but more often.
Schizophrenia and histidine
Histidine is a precursor of the highly active substance histamine. Scientists have found a link between high levels of histamine and schizophrenia, so L-histidine is contraindicated in people with schizophrenia.
Mental health and methionine
Some nutritionists note that an excess of methionine can lead to psychological problems, more often this occurs when there is a lack of magnesium, which actively participates in the first metabolic stage of methionine.
High blood pressure and DL-phenylalanine, L-phenylalanine and tyrosine
If you suffer from high blood pressure, you can take DL-phenylalanine, L-phenylalanine and tyrosine only under the supervision of your consultant. Also you need to regularly measure your blood pressure.
GASTROINTESTINAL TRACT SIDE EFFECTS
Because highly purified amino acids do not contain fibers and are absorbed very quickly, difficulties can occur with bowel evacuation. However, if you follow our dietary guidelines and drinking regimen, you will avoid this problem.